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Choline kinase. Choline kinase catalyzes the first committed step in the phosphorylation of choline to form PC. This reaction is reversible, producing PCho from PC. It is the most specific of all choline metabolic enzymes, and has only one unique substrate, PC. In a so-called “forward” reaction, it specifically phosphorylates choline; in a “reverse” reaction, it dephosphorylates phosphocholine and produces choline. The enzyme is also called phosphocholine-specific phosphokinase.

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Choline transport:
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In brain cells, choline is thought to be involved in brain function by maintaining an appropriate level of the neurotransmitters acetylcholine (ACh) and (S)-adenosyl-L-methionine (SAM). SAM is made in the cell from choline and (S)-methionine. ACh is made from SAM and acetyl coenzyme A (CoA) by the enzyme choline acetyltransferase.

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